Araña

Now, if you're someone who's familiar with a lot of the minutiae of Marvel comics, you might say “But Ryan, there's already a Spider-Girl. She's an alternate-reality daughter of Peter and Mary-Jane Parker, in a reality where she didn't disappear to never be mentioned again after being kidnapped by the Green Goblin.” You'd say that, and you'd be right - but this isn't Spider-Girl, this is Arana, because one teenaged girl with spider-based powers apparently isn't enough for Marvel comics.
I should clarify - while Arana shares some thematic elements with JMS' Spider-Man work, there's no connection to Parker in the story, and it's never actually confirmed the the story takes place in the MU proper; rather, we have a story of secret societies, and spider-spirits, and chosen ones, and it all sounds really interesting, but the story never gets off the ground.