Neuromancer

I first read this in the mid-80's, my only experience with computing was a VIC-20 and a Commodore 64 (1980 & 1982) - the technology in the book was unimaginable for me, pure sci-fi.
I was in my early teens, the drug references were beyond me, it was after this I discovered Burroughs and the Beats.

The Straylight maze and the reference to the palace of the Duke of Mantua now seems contrived, but...

Body augmentation with technology, organ transplant procedures that are common and readily available.

Now re-reading this, you see that like a tanker captain, Gibson was looking over the horizon and in amongst this he is exploring some fairly staple enduring themes, slavery, self determination, evolution, assisted evolution, machine intelligence, squandered potential, etc.

I think I still prefer Pattern Recognition.